Saturday, July 20, 2019
Bisphenol A in polycarbonate is not a Serious Hazard to Human Health Es
Is the Bisphenol A in polycarbonate a serious hazard to human health? Abstract: Polycarbonate, which is a polymer plastic, is found in many bottles and food packaging around the world. However, because Bisphenol A is used in the processing of it, there is a potential danger to humans. Bisphenol A is a molecule that is a hormone inhibitor and also mirrors the function of estrogen. Although the EPA has released a safe level for Bisphenol A ingestion, recent research has shown that those levels may not be safe for humans. Until further testing is done, scientists arenÃ¢â¬â¢t certain of the threshold of BPA intake in humans before dangerous health effects occur. Polycarbonate of Bisphenol A is a thermoplastic polymer that is easily shaped, worked with, and transformed. It has become a popular plastic for manufacturers to use, and they have been under fire recently for making bottles and food packaging out of this possibly potent material. Polycarbonate has the recycling number 7 and usually the letters PC. It contains multiple functional groups linked together by carbonate groups in a molecular chain. In the structure of this repeating molecule, there are the carbonate groups and methyl groups. The polycarbonate of Bisphenol A (BPA) is different from the others because it is processed using that molecule. The synthesis of this type of polycarbonate is as follows: 2 Bisphenol A and sodium hydroxide react to form the sodium salt of Bisphenol A. http://pslc.ws/macrog/pc.htm Then, this molecule is reacted with phosgene. Phosgene was once used as a chemical weapon in World War I, but now is an important component of organic compounds. The molecular formula of phosgene is Cl2CO. http://pslc.ws/macrog/pc.htm Final step in... ...and dose dependency of the pharmacokinetics and metabolism of bisphenol A in neonatal sprague-dawley rats following oral administration. 77(2): 230-242. Elsby, Robert, James Maggs, John Ashby, and Kevin Park. "Comparison of the Modulatory Effects of Human and Rat Liver Microsomal Metabolism on the Estrogenicity of Bisphenol A: Implications for Extrapolation to Humans." Journal of Pharmacology and Experimental Therapeutics 297 (2001). LeGrand, Donald. Handbook of polycarbonate science and technology, NY, 2000. NTP BRIEF ON BISPHENOL A. Rep.No. 80-05-7. National Toxicology Program. 2008. "Plastics chemical bisphenol-A may promote breast cancer." 28 Aug. 2006. 25 July 2008. . Ã¢â¬Å"PolycarbonatesÃ¢â¬ 25 July 2008.